海马体
海马结构
奥特典节律
神经科学
电生理学
昼夜节律
内分泌学
生物
下丘脑
葡萄糖稳态
内科学
化学
医学
糖尿病
胰岛素抵抗
作者
David Tingley,Kathryn McClain,Ekin Kaya,Jordan Carpenter,György Buzsáki
出处
期刊:Nature
[Springer Nature]
日期:2021-08-11
卷期号:597 (7874): 82-86
被引量:40
标识
DOI:10.1038/s41586-021-03811-w
摘要
The hippocampus has previously been implicated in both cognitive and endocrine functions1-15. We simultaneously measured electrophysiological activity from the hippocampus and interstitial glucose concentrations in the body of freely behaving rats to identify an activity pattern that may link these disparate functions of the hippocampus. Here we report that clusters of sharp wave-ripples recorded from the hippocampus reliably predicted a decrease in peripheral glucose concentrations within about 10 min. This correlation was not dependent on circadian, ultradian or meal-triggered fluctuations, could be mimicked with optogenetically induced ripples in the hippocampus (but not in the parietal cortex) and was attenuated to chance levels by pharmacogenetically suppressing activity of the lateral septum, which is the major conduit between the hippocampus and the hypothalamus. Our findings demonstrate that a function of the sharp wave-ripple is to modulate peripheral glucose homeostasis, and offer a mechanism for the link between sleep disruption and blood glucose dysregulation in type 2 diabetes16-18.
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