FOXP3型
生物
效应器
免疫系统
免疫学
过继性细胞移植
细胞生物学
转录因子
自身免疫
神经肽1
人口
免疫耐受
调节性T细胞
T细胞
白细胞介素2受体
癌症研究
遗传学
医学
基因
血管内皮生长因子受体
环境卫生
血管内皮生长因子
作者
Steffie Junius,Adamantios V. Mavrogiannis,Pierre Lemaitre,Margaux Gerbaux,Frederik Staels,Vanshika Malviya,Oliver T. Burton,Vaclav Gergelits,Kailash Singh,Raul Y. Tito,Jeroen Raes,Stephanie Humblet-Baron,Adrian Liston,Susan M. Schlenner
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2021-07-23
卷期号:6 (61)
被引量:2
标识
DOI:10.1126/sciimmunol.abe4723
摘要
Regulatory T cells (Tregs) are indispensable for the control of immune homeostasis and have clinical potential as a cell therapy for treating autoimmunity. Tregs can lose expression of the lineage-defining Foxp3 transcription factor and acquire effector T cell (Teff) characteristics, a process referred to as Treg plasticity. The extent and reversibility of such plasticity during immune responses remain unknown. Here, using a murine genetic fate-mapping system, we show that Treg stability is maintained even during exposure to a complex microbial/antigenic environment. Furthermore, we demonstrate that the observed plasticity of Tregs after adoptive transfer into a lymphopenic environment is a property limited to only a subset of the Treg population, with the nonconverting majority of Tregs being resistant to plasticity upon secondary stability challenge. The unstable Treg fraction is a complex mixture of phenotypically distinct Tregs, enriched for naïve and neuropilin-1-negative Tregs, and includes peripherally induced Tregs and recent thymic emigrant Tregs These results suggest that a "purging" process can be used to purify stable Tregs that are capable of robust fate retention, with potential implications for improving cell transfer therapy.
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