Mn3O4 Nanozyme for Inflammatory Bowel Disease Therapy

Abstract Recently, reactive oxygen species (ROS) scavenging nanozymes have been developed as natural enzyme alternatives to treat inflammatory bowel disease (IBD) as well as other inflammatory diseases. Among them, manganese oxide nanozymes are advantageous because of remarkable biocompatibility and their good biodegradability. It is herein reported that phospholipid coated Mn 3 O 4 nanozymes mimic both superoxide dismutase (SOD) and catalase (CAT) to effectively eliminate ROS that exacerbate inflammation and cause damages to tissues and organs. With the help of phospholipid decoration, the Mn 3 O 4 nanozymes are well dispersed and show good stability. Moreover, the coating enables the successful fluorescence labelling to study their biodistribution and fate. Excitingly, the Mn 3 O 4 nanozymes exhibit superior therapeutic efficacy for both ulcerative colitis (UC) and Crohn's disease (CD) in mouse models over aminosalicylic acid, a first‐line medication for IBD, under the same dosage. Thus, the Mn 3 O 4 nanozymes in this work offer a promising nano‐medication for inflammation‐related disease therapy and broaden the spectrum of biomedical application of nanozymes.