促炎细胞因子
氧化应激
内质网
炎症
活性氧
化学
未折叠蛋白反应
体内
分泌物
药理学
癌症研究
细胞生物学
医学
免疫学
生物化学
生物
生物技术
作者
Xue-Fang Lou,Chen Wang,Ju-Cong Zhang,Yong‐Zhong Du,Xiaoling Xu
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2021-11-03
卷期号:13 (11): 1850-1850
被引量:6
标识
DOI:10.3390/pharmaceutics13111850
摘要
Nanoenzyme-mediated catalytic activity is emerging as a novel strategy for reactive oxygen species (ROS) scavenging in acute lung injury (ALI) treatment. However, one of the main hurdles for these metal-containing nanoenzymes is their potential toxicity and single therapeutic mechanism. Herein, we uncovered a melanin-like nanoparticles derived from the self-polymerization of 1,8-dihydroxynaphthalene (PDH nanoparticles), showing a significant anti-inflammation therapeutic effect on ALI mice. The prepared PDH nanoparticles rich in phenol groups could not only act as radical scavengers to alleviate oxidative stress but could also chelate calcium overload to suppress the endoplasmic reticulum stress response. As revealed by the therapeutic effect in vivo, PDH nanoparticles significantly prohibited neutrophil infiltration and the secretion of proinflammatory cytokines (TNF-α and IL-6), thus improving the inflammatory cascade in the ALI model. Above all, our work provides an effective anti-inflammatory nanoplatform by using the inherent capability of melanin-like nanoenzymes, proposing the potential application prospects of these melanin-like nanoparticles for acute inflammation-induced injury treatment.
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