生物
电池极性
细胞生物学
极性(国际关系)
信号转导
上皮极性
细胞外基质
细胞内
细胞信号
细胞
遗传学
作者
Ruba Halaoui,Luke McCaffrey
出处
期刊:Oncogene
[Springer Nature]
日期:2014-03-17
卷期号:34 (8): 939-950
被引量:147
摘要
Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble polarity complexes function to specify and maintain apical and basolateral membrane domains, which are essential to organize intracellular signaling pathways that maintain epithelial homeostasis. Disruption of apical–basal polarity proteins facilitates rewiring of oncogene and tumor suppressor signaling pathways to deregulate proliferation, apoptosis, invasion and metastasis. Moreover, apical–basal polarity integrates intracellular signaling with the microenvironment by regulating metabolic signaling, extracellular matrix remodeling and tissue level organization. In this review, we discuss recent advances in our understanding of how polarity proteins regulate diverse signaling pathways throughout cancer progression from initiation to metastasis.
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