动脉硬化
同型半胱氨酸
蛋氨酸
主动脉
高同型半胱氨酸血症
内科学
肺栓塞
腹主动脉
吡哆醇
发病机制
医学
栓塞
硫内酯
生物化学
内分泌学
化学
心脏病学
氨基酸
有机化学
作者
Kilmer S. McCully,Robert B. Wilson
标识
DOI:10.1016/0021-9150(75)90004-0
摘要
Arteriosclerotic plaques were found in the aorta and arteries of rabbits given homocysteine thiolactone, methionine or homocysteic acid, both parenterally and in a synthetic diet. Animals given large doses of parenteral methionine or homocysteine thiolactone died of pulmonary embolism and pulmonary infarct. Pyridoxine prevented thrombosis and pulmonary embolism but did not prevent arteriosclerotic plaques. These findings and previous work, showing a new matabolic pathway for sulfate ester synthesis from methionine, the somatotrophic activity of homocysteic acid, and control of cellular growth and intercellular matrix synthesis by homocysteine derivatives, suggest a theory to explain aspects of the pathogenesis of arteriosclerosis.
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