EFFECT OF METOCLOPRAMIDE AND LISURIDE ON HYPOPHYSEAL AND GONADAL FUNCTION IN MEN

SUMMARY The effects of chronic treatment over 7 weeks with metoclopramide and lisuride alone as well as the combination of both drugs were studied on basal and TRH/LHRH stimulated serum PRL, testosterone, LH, FSH, GH, and TSH concentrations. The study was conducted under double‐blind placebo‐controlled conditions and included twenty‐four healthy male volunteers. In addition, repeated seminal fluid analyses were performed before, during and after treatment. While the known PRL‐stimulatory effect of metoclopramide and the PRL‐lowering effect of lisuride could be confirmed, we were unable to demonstrate any substance‐related effects on the other hypophyseal or gonadal hormones. In contrast to previously published data no adverse effects of metoclopramide on sperm analysis could be demonstrated.