合成致死
体细胞
杀伤力
突变
生物
癌细胞
癌症研究
细胞毒性T细胞
基因
背景(考古学)
计算生物学
合成生物学
癌症
遗传学
DNA修复
体外
古生物学
出处
期刊:Nature Reviews Cancer
[Springer Nature]
日期:2005-08-19
卷期号:5 (9): 689-698
被引量:1252
摘要
Two genes are synthetic lethal if mutation of either alone is compatible with viability but mutation of both leads to death. So, targeting a gene that is synthetic lethal to a cancer-relevant mutation should kill only cancer cells and spare normal cells. Synthetic lethality therefore provides a conceptual framework for the development of cancer-specific cytotoxic agents. This paradigm has not been exploited in the past because there were no robust methods for systematically identifying synthetic lethal genes. This is changing as a result of the increased availability of chemical and genetic tools for perturbing gene function in somatic cells.
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