疟疾
青蒿素
计算机科学
药品
药理学
恶性疟原虫
医学
免疫学
作者
Sunny Manohar,Mohit Tripathi,Diwan S. Rawat
标识
DOI:10.2174/1568026614666140808125728
摘要
In recent times, the novel concept of generating hybrid molecules by pharmacophoric hybridisation approach is fast becoming an alternative to other existing strategies of drug development. These hybrids also known as ‘dual drugs’ or ‘double drugs’ are especially found to be effective in overcoming drug resistance problems. Towards this end, a lot of effort has been put for generating 4-aminoquinoline based hybrid molecules as next generation antimalarial drugs effective in malarial chemotherapy. This short review deals about the recent advances carried in the field of 4-aminoquinoline based molecular hybrids as potential antimalarial agents. It also presents a brief and simplified story on the development of 4-aminoquinolines as a mainstay in malarial research programmes. Keywords: 4-Aminoquinoline, antimalarial, artemisinin, hybrid, pfDHFR.
科研通智能强力驱动
Strongly Powered by AbleSci AI