Design and fabrication of hollow fiber-based Raman tweezers for bioparticle measurement

The flexible fiber optic probe for laser trapping Raman spectroscopy is developed to analyze single bio-particles in vivo. The probe consists of the hollow optical fiber and TiO2 micro-lens. Red blood cell and yeast are stably trapped by the fabricated probe. The Raman measurement of PMMA particle having 10 μm diameters is also demonstrated.