First, quadratic regression general rotary combination experimental design is adopted in this paper. The cutting force prediction model based on tool rake angle and helix angle is established using regression analysis. And the proper cutter for milling Ti6Al4V is selected, rake angle = 12.5 °, helix angle = 34.5 °.Secondly, milling temperature during different milling process is simulated by the use of finite element simulation software. And the variation rule of milling temperature along with the rake angle and helix angle is obtained which provided the basis for the selecting tool.