Research on the preparation and characterization of chitosan grafted polyvinylpyrrolidone gel membrane with iodine

ABSTRACT The chitosan grafted polyvinylpyrrolidone gel membrane with iodine (CS‐PVP‐I 2 ‐G‐M) was prepared by chitosan–polyvinylpyrrolidone–iodine complex liquid (CS‐PVP‐I 2 ‐L) mixed with gelatin. The intermediate product CS‐PVP‐I 2 ‐L was prepared by CS grafted PVP in the protection of N 2 with dimethyl 2,2′‐azobis (2‐methylpropionate) (AIBME) as initiator, then a certain amounts of iodine in ethanol solution was added. The properties of CS‐PVP‐I 2 ‐G‐M were characterized by IR, UV–Vis, SEM, XRD, DSC, and so forth. The iodine release results coherent with the release kinetic model—Fick diffusion laws, has a burst effect first, and then spread, and the emission of iodine was maintained within a certain range and kept at a stable level permanently, showed a sustained‐release effect of iodine. The inhibition zone diameters of CS‐PVP‐I 2 ‐G‐M against Staphylococcus aureus and Escherichia coli were both greater than 16 mm, it demonstrated significant antibacterial activity. Double effects sustained‐release effect of iodine and the significant antibacterial activity made CS‐PVP‐I 2 ‐G‐M highly potential for applications as a novel natural biomedical sterilization materials. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41797.