New Cytotoxic Triterpenoids from the Aerial Parts of Euphorbia sieboldiana

Abstract Phytochemical investigation of the EtOH extract of Euphorbia sieboldiana led to the isolation of four new oleanane‐type triterpenoids, (1 β ,2 α ,3 β ,19 β )‐1,2,3,19‐tetrahydroxyolean‐12‐en‐28‐oic acid, (1 β ,3 β ,19 β )‐1,3,19‐trihydroxyolean‐12‐en‐28‐oic acid, (1 β ,2 α ,3 β ,16 β ,19 β )‐1,2,3,16,19‐pentahydroxyolean‐12‐en‐28‐oic acid, and (1 β ,2 α ,3 β ,19 β ,23)‐1,2,3,19,23‐pentahydroxyolean‐12‐en‐28‐oic acid, along with 16 known compounds. Their structures were established by extensive 1D‐ and 2D‐NMR, as well as other spectral analyses. Biological evaluation of the four new triterpenoids revealed potent cytotoxic activities against HeLa and Hep‐G2 cells.