Ultrasonic testing instrumentation is thicker steel plate automatic ultrasonic testing system’ s core modules,Application of PXI technology increases the ultrasonic testing instrumentation integration and reliability and brings enterprises with huge economic returns.The paper introduces the PXI Technology architecture,presents the program of multi-channel ultrasonic testing instrumentation based on PXI and elaborates the application of PXI extensions for instrumentation in ultrasonic testing instrumentation.It is shown that the PXI technology is open,modular and high-performance in practical applications.Application of the technology in the ultrasonic testing instrumentation meets business needs and has practical significance in the field of NDT(Non-Destructive Testing).