Post-operective anticoagulant effects of rivaroxaban on hip or knee arthroplasty

Objective To investigate the therapeutic effect and safety of rivaroxaban on preventing lower extremity deep vein thrombosis in hip or knee arthroplasty post-operative patients.MethodsTwo hundred and five patients after hip or knee arthroplasty were allocated to two groups.Rivaroxaban group(94 cases) was treated with rivaroxaban 10 mg,orally once a day for 14 days,and enoxaparin group(111 cases) treated with enoxaparin subcutaneously injected every 12 hours for 10 days.Before operation,lower extremity deep vein thrombosis was not found in all of the collected patients.After 14 days,color ultrasonography on double lambs vain was used to find out any deep vein thrombosis,and the pulmonary embolism or serious bleeding.ResultsThe incidence rate of deep vein thrombosis in the rivaroxaban treatment group(2.13%) was obviously lower than the enoxaparin group(9.00%).No pulmonary embolism or serious bleeding occurred.ConclusionRivaroxaban to prevent lower extremity deep vein thrombosis in hip or knee arthroplasty post-operative patients was better than enoxaparin,both are safe and with less serious bleeding.