Study on the obesity and insulin resistance of polycystic ovary syndrome

Objective To investigate the features of obesity and insulin resistance in polycystic ovary syndrome patients,and to analyze the relation of these clinical parameters to biochemical features.Methods Two hundred and seventy-six polycystic ovary syndrome patients were divided into obese group and no-obese group.The level of blood sugar and insulin,area under curve of insulin,the length of menses were compared between obese group and no-obese group.The relation of area under curve of insulin to biochemical features was analyzed.Results(1) Insulin resistance and the impaired glucose tolerance were not always congruity.(2) Compared with polycystic ovary syndrome patients without obese,the rate of insulin resistance was significantly higher in obese polycystic ovary syndrome patients(P0.05),and the length of menses was longer in obese polycystic ovary syndrome patients.(3) Insulin area under the curve was positively correlated with BMI and T,negatively correlated with ratio of LH/FSH.Conclusion Insulin resistance is common in polycystic ovary syndrome patients.Compared with polycystic ovary syndrome patients without obese,the rate of insulin resistance is significantly higher in obese group(P0.05).Obesity is an important risk factor for polycystic ovary syndrome patients,and it can aggravate the clinical signs of polycystic ovary syndrome.