金黄色葡萄球菌
四周大雄性仓鼠
皮下注射
菌血症
细菌
仓鼠
葡萄球菌感染
微生物学
生物
接种
金仓鼠
葡萄球菌
医学
免疫学
病理
抗生素
内分泌学
遗传学
作者
Thomas M. Donnelly,Stark Dm
出处
期刊:PubMed
日期:1985-12-01
卷期号:46 (12): 2634-8
被引量:1
摘要
Response of rodents to experimentally induced subcutaneous infection was examined to determine whether laboratory rats used in invasive procedures have a superior ability to withstand wound infection than do hamsters and mice. Rats, hamsters, and mice were injected subcutaneously with 10(9), 10(7), and 10(5) colony-forming units of Staphylococcus aureus. Quantitative counts of viable S aureus from the injection site, bacteriologic cultures of heart blood, and histologic examinations of the subcutaneous tissues were performed. Multiple linear regression of the quantitative data and equality of regression lines among groups were determined. Results indicated that the ability to eliminate bacteria varied between species and depended on the dose injected within each species. Compared with hamsters and mice at all doses, rats eliminated bacteria faster and had the mildest and most rapidly organized inflammatory response after inoculation. Experimental bacteremia developed in 3.7% of all animals evaluated, with no species-specific pattern. The rat was more resistant to localized wound infection with S aureus than were hamsters and mice.
科研通智能强力驱动
Strongly Powered by AbleSci AI