Anti-inflammatory and immunoregulatory effect of octreotide on acute pancreatitis

Objective:To investigate the effect of octreotide on the anti-inflammation and immunoregulation for patients with acute pancreatitis.Methods:A total of 60patients with acute pancreatitis were randomly divided into experimental group(n=30)and control group(n=30).The patients in control group were treated with conventional treatment,and those in experimental group were treated with the conventional treatment and intravenous octreotide injection.Results:Compared with control group,the endogenic inflammatory factors including serum TNF-αand IL-6were significantly decreased and the immunoglobulin including IgG and IgM were significantly increased inexperimental group(P0.05).Conclusion:Octreotide has obvious anti-inflammatory effect and could up-regulate the immune function,which is helpful for the treatment of acute pancreatitis.