Objectire To investigate the characteristics of odontogenic keratocyst in diagnosis and treatment. Methods:According to clinical symptoms,x-ray and surgery, 78 cases of odontogenic keratocyst were studied, Results:All of the patients hare been followed up for 2-5 years. The recarrence rate was 11.54%. The best method was operation plus freezing. Conclusion Diagnosis and treatment of odontogenic keratocyst can be correctly got through its clinical symptoms and x-ray features.