Influence of Endotoxin on Small Intestinal Mucosa and Protective Effects of CA in Rats

This study was to explore the influence of endotoxin(ET)on small intestinal mucosa tissue and the protective effects of CA in rats.72 SD rats were randomly divided into three groups:the control group,ET group and CA group,after appropriate treatment the duodenum,jejunum tissue were collected and tested at 3,4,8,12 h.The pathological slices of above tissues were prepared and stained by H.E.,then were analyzed by graphical analysis system.The length of the intestinal villi of the duodenum and jejunum in ET group were shorter than in control and CA group at 3,4,8,12h(P0.01).The quantity of IEL in the duodenum and jejunum in ET group were less than that of control and CA group at 3,4,8,12h(P0.01).The quantities of IEL in the duodenum and jejunum in CA group were more than that of ET group at 4,8,12h(P0.01).The results indicated that ET could destroy the normal structures of small intestine,reduce the length of the intestinal villi,and consequently affect the normal absorptive and immune function.However,CA has protective effects by significantly relieving the toxic effects of ET.