Experimental research on the effect of Propofol on spatial learning and memory in rats

Aim To investigate the effect of propofol on the spatial learning and memory in rats. Methods An intraperitoneal (ip) injection of several doses (10, 30, 75 mg·kg-1) of propofol was performed. Intralipid was given (ip) as control. Then, rats were subjected to Morris water maze to evaluate the spatial learning and learning. Results Spatial learning and memory was impaired by repeated 30 and 75 mg·kg-1 Propofol (ip). However, 10 mg·kg-1 propofol had no effect on the spatial learning and memory. Conclusion Multiple repeated anesthesia or sedation by propofol induces the impairment of spatial learning and memory in rats.