With kaolin mixed sepiolite as raw materials and by in-situ crystallization a catalyst is prepared for FCC catalyst.The effects of sepiolite on the crystallinity,SiO2/Al2O3 and anti-vanadium performance are investigated.The results show that the in-situ crystallized product with sepiolite has lower crystallinity and higher Si/Al ratio than those with the none-sepiolite,and the crystallinity and SiO2/Al2O3 ratio change a little with the sepiolite content between 5%-30%.Under the condition as 100% of water vapor,800℃ and 17 hours,the activity of the FCC catalyst with sepiolite is lower than that without sepiolite,but the activity retention rate can be 25% higher after polluted with 5 000 ppm of vanadium compared with that without sepiolite,which shows that the catalyst with sepiolite has high anti-vanadium performance.