Progress on Gut Mucosal Immunization

Mucosal immunization is one of the most important immune routines in immunology,especially gut mucosal immunization.In recent years,the effects on mucosal immunization of gut mucosal tissue structure,intestinal microflora and mucosal vaccines have been studied generally.The results showed that it was M cell,dendritic cell and macrophage to uptake and transport antigens in gut mucosal tissues,which was important to initiate the mucosal immunization.Intestinal microflora could promote the secretion of antigens and regulate the production of cytokines.Good mucosal vaccines could efficiently arouse mucosal immunization reaction,which was convenient,fast,safe,effective and persistent.Especially we explained the effects on mucosal immunization of intestinal microflora and the advantages of mucosal immunity,and analyzed the key restrict factors,the existing problems and prospects of mucosal immunity.