炎症
细胞外
信号转导
细胞生物学
细胞内
蛋白质家族
细胞代谢
细胞
生物
免疫学
生物化学
基因
作者
Gopalkrishna Sreejit,Michelle Flynn,Mallikarjun Patil,Prasanna Krishnamurthy,Andrew Murphy,Prabhakara R Nagareddy
出处
期刊:Advances in Clinical Chemistry
日期:2020-01-01
卷期号:: 173-231
被引量:48
标识
DOI:10.1016/bs.acc.2020.02.006
摘要
The S100 family proteins possess a variety of intracellular and extracellular functions. They interact with multiple receptors and signal transducers to regulate pathways that govern inflammation, cell differentiation, proliferation, energy metabolism, apoptosis, calcium homeostasis, cell cytoskeleton and microbial resistance. S100 proteins are also emerging as novel diagnostic markers for identifying and monitoring various diseases. Strategies aimed at targeting S100-mediated signaling pathways hold a great potential in developing novel therapeutics for multiple diseases. In this chapter, we aim to summarize the current knowledge about the role of S100 family proteins in health and disease with a major focus on their role in inflammatory conditions.
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