Objective:To evaluate the Biocompatibility of gelatin-Bletilla hyacinthine gum(BHG) carrying Sanguis Draconis.Methods:The Sanguis Draconis impalpable powder was compounded with scaffolds(gelatin and BHG).Then it was frozen and dried to form spongy and porous material.The acute systemic toxicity,sensitization,skin irritation,pyrogen and cytotoxicity test were conducted to evaluate the biocompatibility of the spongy and porous biomaterial.Results:All the contents of Biocompatibility evaluation test consisting of acute systemic toxicity,sensitization,skin irritation,pyrogen and cytotoxicity met the requirement of standards.Conclusion:The biomaterial carrying Sanguis Draconis prepared in this study has good cytocompatibility,and it is a safe biomaterial for wound healing and tissue engineering.