作者
Sang-Ho Kang,Ramesh Prasad Pandey,Chang-Muk Lee,Joon-Soo Sim,Jin-Tae Jeong,Beom-Soon Choi,Myunghee Jung,Daniel Ginzburg,Kangmei Zhao,So Youn Won,Tae‐Jin Oh,Yeisoo Yu,Nam Hoon Kim,Ok Ran Lee,Tae‐Ho Lee,Puspalata Bashyal,Taesu Kim,Woo-Haeng Lee,Charles Hawkins,Chang-Kug Kim,Jung Sun Kim,Byoung Ohg Ahn,Seung Y. Rhee,Jae Kyung Sohng
摘要
Senna tora is a widely used medicinal plant. Its health benefits have been attributed to the large quantity of anthraquinones, but how they are made in plants remains a mystery. To identify the genes responsible for plant anthraquinone biosynthesis, we reveal the genome sequence of S. tora at the chromosome level with 526 Mb (96%) assembled into 13 chromosomes. Comparison among related plant species shows that a chalcone synthase-like (CHS-L) gene family has lineage-specifically and rapidly expanded in S. tora. Combining genomics, transcriptomics, metabolomics, and biochemistry, we identify a CHS-L gene contributing to the biosynthesis of anthraquinones. The S. tora reference genome will accelerate the discovery of biologically active anthraquinone biosynthesis pathways in medicinal plants.