神经退行性变
活性氧
氧化应激
发病机制
疾病
神经科学
阿尔茨海默病
淀粉样蛋白(真菌学)
医学
生物
病理
细胞生物学
生物化学
作者
Shvetank Bhatt,Lakshman Puli,Chandragouda R. Patil
标识
DOI:10.1016/j.drudis.2020.12.004
摘要
The pathogenesis of Alzheimer's disease (AD) involves neurodegeneration following the deposition of β-amyloid (Aβ) plaques and neurofibrillary tangles in vulnerable brain regions. The vulnerability of the brain to reactive oxygen species (ROS) is now emerging as a key detrimental factor driving AD pathogenesis. Oxidative stress (OS) irreversibly damages cellular biomolecules and perturbs neuronal functions. Scientific evidence is emerging that supports the therapeutic effects of antioxidants in preventing the onset and delaying the progression of AD pathology. In this review, we highlight the role of the OS in AD and the importance of antioxidants in its treatment.
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