黑色素瘤
适应性
基因工程
转移性黑色素瘤
癌症研究
免疫系统
医学
靶向治疗
计算生物学
免疫学
生物
癌症
内科学
基因
遗传学
生态学
作者
Vito W. Rebecca,Rajasekharan Somasundaram,Meenhard Herlyn
标识
DOI:10.1038/s41467-020-15546-9
摘要
Abstract Metastatic melanoma is challenging to manage. Although targeted- and immune therapies have extended survival, most patients experience therapy resistance. The adaptability of melanoma cells in nutrient- and therapeutically-challenged environments distinguishes melanoma as an ideal model for investigating therapy resistance. In this review, we discuss the current available repertoire of melanoma models including two- and three-dimensional tissue cultures, organoids, genetically engineered mice and patient-derived xenograft. In particular, we highlight how each system recapitulates different features of melanoma adaptability and can be used to better understand melanoma development, progression and therapy resistance.
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