The role of MUC2 mucin in intestinal homeostasis and the impact of dietary components on MUC2 expression

MUC2 mucin is an important secretory protein found in the human gut. Recent studies indicated that MUC2 mucin plays a role in the protection of gut barrier, the regulation of microbiome homeostasis and the prevention of diseases. In this review, the physiological properties of MUC2 mucin and its interactions with the intestinal microbiome are firstly discussed. Its roles in intestinal diseases including inflammatory bowel disease, colorectal cancer and parasitic infections are concluded. We also reviewed dietary components known to have modulative effects on MUC2 mucin expression, such as polysaccharides, amino acids and polyphenols.