Total Synthesis of Atisane-Type Diterpenoids and Related Diterpenoid Alkaloids

Atisane-type compounds and related natural products are attractive for their molecular skeletons and pharmaceutical bioactivities. This review summarizes total syntheses of atisane-type diterpenoids and related diterpenoid alkaloids. 1 Introduction 2 Total Synthesis and Synthetic Studies of Atisane-Type Diterpenoids and Related Diterpenoid Alkaloids 2.1 Ionic Methods 2.1.1 S N 2 Substitution Reaction 2.1.2 Aldol Reaction 2.1.3 Intramolecular Double Michael Addition 2.2 Free-Radical Methods 2.2.1 Free-Radical Rearrangement 2.2.2 Free-Radical Addition 2.3 Diels–Alder Cycloaddition 3 Conclusion