生物膜
胞外聚合物
石墨烯
氧化物
纳米复合材料
银纳米粒子
铜绿假单胞菌
化学
微生物学
纳米技术
抗菌剂
细胞外
生物物理学
化学工程
细菌
材料科学
纳米颗粒
生物化学
有机化学
生物
遗传学
工程类
作者
Shima Liu,Shuting Cao,Jun Guo,Liqiang Luo,Yi Zhou,Chenglie Lin,Jiye Shi,Fan Chen,Min Lv,Lihua Wang
出处
期刊:Nanoscale
[The Royal Society of Chemistry]
日期:2018-01-01
卷期号:10 (41): 19603-19611
被引量:39
摘要
Biofilms with positive and negative actions ubiquitously affect medical infections, environmental remediation and industrial processes. However, it remains challenging to control the growth of harmful biofilms as well as to exploit the use of beneficial biofilms. Here we investigated the effect of an antibacterial graphene oxide-silver nanoparticles (GO-AgNPs) composite on Pseudomonas aeruginosa biofilm formation. We found that GO-AgNPs prevented biofilm formation in a dose-dependent manner, with a threshold of 15 μg mL-1. Interestingly, the bacterial biomass significantly decreased, but extracellular polymeric substance (EPS) production remarkably increased in mature biofilms treated with GO-AgNPs of an appropriate concentration, suggesting that GO-AgNPs effectively modulate biofilm development and structure. Moreover, we established that GO-AgNPs caused bacterial death via both physical damage and oxidative stress, showing the synergic action of GO and AgNPs. These findings facilitate the use of graphene-based nanocomposites for greener antibiotic applications.
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