化学
生物医学中的光声成像
急性肾损伤
经济短缺
肾
信号(编程语言)
分子成像
小分子
生物医学工程
纳米技术
内科学
体内
光学
生物化学
医学
政府(语言学)
程序设计语言
生物技术
材料科学
计算机科学
哲学
物理
生物
语言学
作者
Wangning Zhang,Fangjian Cai,Haijun Xu,Yan Wu,Xie‐an Yu,Lei Sun,Tiange Zhang,Boyang Yu,Xianchuang Zheng,Jiangwei Tian
标识
DOI:10.1021/acs.analchem.2c01106
摘要
Acute kidney injury (AKI) has become a growing issue for patients with the extensive use of all kinds of drugs in clinic. Photoacoustic (PA) imaging provides a noninvasive and real-time imaging method for studying kidney injury, but it has inherent shortages in terms of high background signal and low detection sensitivity for exogenous imaging agents. Intriguingly, J-aggregation offers to tune the optical properties of the dyes, thus providing a platform for developing new PA probes with desired performance. In this study, a small-molecule PA probe (BDP-3) was designed and synthesized. We serendipitously discovered that BDP-3 can transform into renal clearable nanoaggregates under physiological conditions. The hydrodynamic diameter of the BDP-3 increased from 0.64 ± 0.11 to 3.74 ± 0.39 nm when the content of H2O increased from 40 to 90%. In addition, it was surprising that such a transforming process can significantly enhance its PA amplitude (2.06-fold). On this basis, PA imaging with BDP-3 was applied as a new method for the noninvasive detection of AKI induced by anticancer drugs, traditional Chinese medicine, and clinical contrast agents in animal models and exhibited higher sensitivity than the conventional serum index test, demonstrating great potential for further clinical diagnostic applications.
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