医学
灌注
侧支循环
灌注扫描
核医学
内科学
心脏病学
秩相关
冲程(发动机)
强度(物理)
接收机工作特性
机器学习
机械工程
物理
量子力学
工程类
计算机科学
作者
Arne Potreck,E. Scheidecker,Charlotte S. Weyland,Ulf Neuberger,Christian Herweh,Markus A Möhlenbruch,Mingshui Chen,Simon Nagel,Martin Bendszus,Fatih Seker
出处
期刊:American Journal of Neuroradiology
[American Society of Neuroradiology]
日期:2022-06-09
卷期号:43 (7): 960-965
被引量:4
摘要
BACKGROUND AND PURPOSE:
Information of collateral flow may help to determine eligibility for thrombectomy. Our aim was to identify CT perfusion–based surrogate parameters of good collateral status in acute anterior circulation ischemic stroke. MATERIALS AND METHODS:
In this retrospective study, we assessed the collateral status of 214 patients who presented with acute ischemic stroke due to occlusion of the MCA M1 segment or the carotid terminus. Collaterals were assessed on dynamic CTA images analogous to the multiphase CTA score by Menon et al. CT perfusion parameters (time-to-maximum, relative CBF, hypoperfusion intensity ratio, and CBV-index) were assessed with RAPID software. The Spearman rank correlation and receiver operating characteristic analyses were performed to identify the parameters that correlate with collateral scores and good collateral supply (defined as a collateral score of ≥4). RESULTS:
The Spearman rank correlation was highest for a relative CBF < 38% volume (ρ = −0.66, P < .001), followed by the hypoperfusion intensity ratio (ρ = −0.49, P < .001), CBV-index (ρ = 0.51, P < .001), and time-to-maximum > 8 seconds (ρ = −0.54, P < .001). Good collateral status was better identified by a relative CBF < 38% at a lesion size <27 mL (sensitivity of 75%, specificity of 80%) compared with a hypoperfusion intensity ratio of <0.4 (sensitivity of 75%, specificity of 62%), CBV-index of >0.8 (sensitivity of 60%, specificity of 78%), and time-to-maximum > 8 seconds (sensitivity of 68%, specificity of 76%). CONCLUSIONS:
Automated CT perfusion analysis allows accurate identification of collateral status in acute ischemic stroke. A relative CBF < 38% may be a better perfusion-based indicator of good collateral supply compared with time-to-maximum, the hypoperfusion intensity ratio, and the CBV-index.
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