Store-Operated Calcium Entry in the Cardiovascular System

Calcium (Ca2+) is a critical regulator of cardiovascular function. The Ca2+ channels, pumps, and exchangers contributing to cytosolic Ca2+ signals governing cardiac contraction and vascular tone are well known. In addition to these Ca2+ components, store-operated calcium entry (SOCE) is a ubiquitous mechanism recently recognized underlying cardiovascular function maintenance and disease development and progression. With this review article, we hope to highlight the accumulated knowledge about the SOCE machinery and its potential contribution to cardiac and vascular function and its roles in cardiovascular pathogenesis and pathology.