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Effect of 1,25(OH)2-vitamin D3 on decidualization of human endometrial stromal cells

蜕膜化 间质细胞 滋养层 内分泌学 内科学 蜕膜细胞 蜕膜 内质网 催乳素 子宫内膜 男科 生物 化学 细胞生物学 怀孕 胎儿 医学 激素 胎盘 遗传学
作者
Hossein Hosseinirad,Shahrokh Paktinat,Fatemeh Mohanazadeh Falahieh,Maryam Mirani,Armin Karamian,Amin KaramianShamsMofarahe
出处
期刊:Steroids [Elsevier BV]
卷期号:180: 108978-108978 被引量:4
标识
DOI:10.1016/j.steroids.2022.108978
摘要

Decidualization is the differentiation of endometrial stromal cells (eSC) to rounded, epithelioid-like cells during menstrual cycle and pregnancy. The impairment of this process leads to infertility and a variety of pregnancy disorders, including recurrent miscarriages and uteroplacental disorders. The aim of this study was to evaluate the effect of 1,25(OH)2-vitamin D3 (VD) on transformation of primary eSC into decidual cells. After isolation of eSC from biopsy samples of healthy fertile women and their characterization, the cells were cultured and propagated, and confluent cultures were decidualized for 12 days with progesterone (P4) and estradiol (E2) in presence or absence of VD. Prolactin (PRL) concentration was measured every 48 h in culture medium of eSCs, and ultrastructural changes were evaluated at the end of treatment. The results showed that PRL concentration in culture medium of eSCs was significantly increased in VD-treated decidual cells compared to control groups in a time-dependent manner. Ultrastructural analysis demonstrated that VD enhances many of the ultrastructural changes of decidualized cells including expansion of rough endoplasmic reticulum (rER), increased lipid droplets and high number of euchromatin round nuclei. These results suggest that VD may play an important role during early pregnancy by promoting cellular transformation associated with decidualization.

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