蔷薇花
生物
微生物群
基因组
蛋白质组
肠道菌群
心肌梗塞
丁酸盐
生理学
粪便
拟杆菌
内科学
疾病
微生物学
免疫学
细菌
生物信息学
遗传学
食品科学
医学
基因
发酵
作者
Cheng‐Lin Liu,Zhonghan Sun,Shalaimaiti Shali,Zhendong Mei,Shufu Chang,Hongxiang Mo,Lili Xu,Yanni Pu,Huihui Guan,Guo‐Chong Chen,Qibin Qi,Zhe‐Xue Quan,Ji Qi,Kang Yao,Yi Dai,Yan Zheng,Junbo Ge
标识
DOI:10.1016/j.jgg.2021.12.007
摘要
Emerging evidence has highlighted the role of gut microbiome in human health. However, the integrative role of gut microbiome and microbial metabolites in acute myocardial infarction (AMI) remains unclear. The current study profiles the microbial community through 16S rRNA gene sequencing and shotgun metagenomic sequencing and measures fecal short-chain fatty acids and circulating choline pathway metabolites among 117 new-onset AMI cases and 78 controls. Significant microbial alternations are observed in AMI patients compared with controls (P = 0.001). The abundances of nine species (e.g., Streptococcus salivarius and Klebsiella pneumoniae) are positively associated, and one species (Roseburia hominis) is inversely associated with AMI status and severity. A gut microbial score at disease onset is associated with the risk of major adverse cardiovascular events in 3.2 years (hazard ratio [95% CI]: 2.01 [1.04-4.24]) in AMI patients. The molar proportions of fecal acetate and butyrate are higher, and the circulating levels of choline and carnitine are lower in AMI patients than in controls. In addition, disease classifiers show that AMI cases and controls have a more distinct pattern in taxonomical composition than in pathways or metabolites. Our findings suggest that microbial composition and functional potentials are associated with AMI status and severity.
科研通智能强力驱动
Strongly Powered by AbleSci AI