Broadband homonuclear decoupled HSQMBC methods

Abstract Long‐range heteronuclear coupling constants convey invaluable information for stereochemical and conformational analysis of molecules from synthetic and natural origin. Here, we report a real‐time Zangger‐Sterk CPMG‐HSQMBC method for the precise and direct measurement of multiple‐bond heteronuclear couplings. It is demonstrated that the real‐time acquisition strategy combined with multiple slice selective excitation can provide substantial improvement in sensitivity (or reduction of experimental time) as compared to other variants of broadband homonuclear decoupled HSQMBC methods published previously. Scope and limitations of the different strategies applied for decoupling are reviewed. Moreover, practical guidelines for the choice of the most appropriate method are also presented. Applications are given on a metal complex incorporating P‐heterocycles and two diglycosyl‐selenides for the extraction of nJ(1H, 31P) and nJ(1H, 77Se), respectively.