白血病
急性白血病
医学
肿瘤科
内科学
癌症研究
作者
Eytan M. Stein,Guillermo Garcia‐Manero,David Alan Rizzieri,Raoul Tibes,Jesús G. Berdeja,Michael Robert Savona,Mojca Jongen‐Lavrencic,Jessica Kaplan Altman,Blythe G. Thomson,Stephen J. Blakemore,Scott R. Daigle,Nigel J. Waters,A. Benjamin Suttle,Alicia Clawson,Roy M. Pollock,Andrei V. Krivtsov,Scott A. Armstrong,Jorge F. DiMartino,Eric E. Hedrick,Bob Löwenberg
出处
期刊：Blood
[Elsevier BV]
日期：2018-05-03
卷期号：131 (24): 2661-2669
被引量：474
标识
DOI：10.1182/blood-2017-12-818948
摘要
Key Points Pinometostat demonstrates first evidence of DOT1L target inhibition and clinical responses in a subset of MLL-r advanced leukemia patients. The observed safety profile of pinometostat shows potential for exploration of combination therapies in leukemia.
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(2025-6-4)
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