Metabolic interactions between acetaminophen (paracetamol) and two flavonoids, luteolin and quercetin, throughin-vitroinhibition studies

Inhibition of human CYP activity by luteolin and quercetin occurred with IC₅₀ values exceeding customary in-vivo human exposure with tolerable supplemental doses of these compounds. The findings indicate that luteolin and quercetin are not likely to be of clinical value for preventing or treating APAP-induced hepatotoxicity.