增强子
生物
转录因子
发起人
Ccaat增强子结合蛋白
基因表达
福克斯A1
糖皮质激素受体
信号转导
基因表达调控
CREB1号
分子生物学
细胞生物学
抄写(语言学)
基因
核蛋白
奶油
生物化学
哲学
语言学
作者
Jeffrey M. Rosen,Shannon L. Wyszomierski,Darryl L. Hadsell
标识
DOI:10.1146/annurev.nutr.19.1.407
摘要
▪ Abstract Studies using both transgenic mice and transfected mammary epithelial cells have established that composite response elements containing multiple binding sites for several transcription factors mediate the hormonal and developmental regulation of milk protein gene expression. Activation of signal transduction pathways by lactogenic hormones and cell-substratum interactions activate transcription factors and change chromatin structure and milk protein gene expression. The casein promoters have binding sites for signal transducers and activators of transcription 5, Yin Yang 1, CCAAT/enhancer binding protein, and the glucocorticoid receptor. The whey protein gene promoters have binding sites for nuclear factor I, as well as the glucocorticoid receptor and the signal transducers and activators of transcription 5. The functional importance of some of these factors in mammary gland development and milk protein gene expression has been elucidated by studying mice in which some of these factors have been deleted.
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