Metal‐Organic Frameworks as Single‐Site Solid Catalysts for Asymmetric Reactions

Abstract This review documents the evolution of chiral MOF catalysts from simple Lewis acid and Lewis base catalysts that afford limited selectivity to more recent advancements that exhibit high stereo‐ and regioselectivities. MOF‐based catalysts provide unprecedented opportunities for interrogating structure‐activity relationships at high structural precision and for controlling catalytic activity by using external stimuli. The most notable disadvantage of MOF‐based catalysts has been the inherent instability of the materials. This hurdle, which effectively limits the reaction scope of MOF catalysts, is slowly being overcome by the advent of new binding moieties and secondary building units.