氧化应激
抗氧化剂
神经炎症
紫色红曲霉
乙酰胆碱酯酶
β淀粉样蛋白
化学
淀粉样蛋白(真菌学)
药理学
老年斑
生物标志物
阿尔茨海默病
生物化学
医学
发酵
疾病
内科学
酶
病理
红曲霉
肽
作者
Chien-Li Chen,Kuang-Yao Chang,Tzu‐Ming Pan
标识
DOI:10.1016/j.jff.2015.12.017
摘要
Oxidative stress and neuroinflammation induced by accumulation of amyloid β (Aβ) and phosphorylated tau protein (p-tau) are the main causes of Alzheimer's disease (AD). We examined the effects of Monascus purpureus NTU 568 fermented product (ANKASCIN 568 plus) in the model of Sprague–Dawley rats via oral garage to induce AD pathology which received aluminium chloride on a daily basis. ANKASCIN 568 plus mitigated cognitive impairment in behavioural tests, reduced oxidative stress in the brain, reversed aluminium-induced AD brain pathology including accumulation of Aβ, p-tau, and amyloid precursor protein; elevated acetylcholinesterase activity, and altered biomarker levels in the cerebrospinal fluid. ANKASCIN 568 plus showed a significant improvement relative to Aricept, an approved drug for AD, in several parameters. Thus, by suppressing free radical generation and activating antioxidant enzymes, ANKASCIN 568 plus can reduce oxidative stress and ameliorate AD pathology, thus protecting rats against aluminium-induced memory and learning deficits.
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