抗生素
抗生素耐药性
生物降解
微生物学
微生物降解
转化(遗传学)
细菌
化学
生物
计算生物学
生态学
微生物
基因
遗传学
生物化学
作者
Ana C. Reis,Boris A. Kolvenbach,Olga C. Nunes,Philippe F.-X. Corvini
标识
DOI:10.1016/j.nbt.2019.08.003
摘要
Antibiotic residues are widespread in the environment and their presence is known to contribute to the propagation of antibiotic resistance. Nevertheless, knowledge on processes involved in their degradation is scattered. This second part of a two part review aims at compiling knowledge on the (bio-) degradation of antibiotics, focusing on β-lactams, macrolides, quinolones and ionophores, as well as some less common classes. Detailed metabolic and molecular aspects are discussed, as well as the role of antibiotic degraders in natural microbial communities. This exercise led to the conclusion that among the classes analyzed, the majority of antibiotics are prone to microbial cleavage or transformation.
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