铜
丝素
表面改性
化学
X射线光电子能谱
催化作用
氧化物
螯合作用
无机化学
水溶液中的金属离子
离子
化学工程
丝绸
核化学
材料科学
有机化学
复合材料
物理化学
工程类
作者
Jinsheng Hua,Hui Yang,Xiufang Li,Jiahui Xiao,Shunshun Zhou,Renchuan You,Likun Ma
出处
期刊:Biointerphases
[American Institute of Physics]
日期:2022-05-01
卷期号:17 (3)
被引量:2
摘要
In situ release of nitric oxide (NO) has been suggested to be a potential functionalization strategy for blood-contacting implants. In this study, the NO generation capability catalyzed by the copper ion-incorporated silk fibroin (SF) films in the presence of S-nitroso-N-acetyl-dl-penicillamine (SNAP) is demonstrated. Cu(II) is effectively bound to the surface of the SF film based on metal–protein coordination. The x-ray photoelectron spectroscopy results indicate that copper ions may exist on the surface of the SF film in the form of Cu(II)/Cu(I) coexistence. The degradation behavior showed that the bound copper ions on the surface of the SF films can maintain a slow release in phosphate-buffered saline (PBS) or collagenase IA solution for 7 days. There was no significant difference in the release of copper ions between PBS degradation and enzyme degradation. The loading of copper ions significantly improved the release of NO from SNAP through catalysis. Based on the biological effects of copper ions and the ability to catalyze the release of NO from S-nitrosothiols, copper ion loading provides an option for the construction of bioactive SF biomaterials.
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