免疫系统
过继性细胞移植
肿瘤浸润淋巴细胞
FOXP3型
抗原
癌症研究
T细胞
免疫学
生物
头颈部鳞状细胞癌
免疫疗法
癌症
头颈部癌
遗传学
作者
Rebekka Duhen,Olivier Fesneau,Kimberly Samson,Alexandra K. Frye,Michael Beymer,Venkatesh Rajamanickam,David Ross,Eric Tran,Brady Bernard,Andrew D. Weinberg,Thomas Duhen
摘要
CD4+ Th cells play a key role in orchestrating immune responses, but the identity of the CD4+ Th cells involved in the antitumor immune response remains to be defined. We analyzed the immune cell infiltrates of head and neck squamous cell carcinoma and colorectal cancers and identified a subset of CD4+ Th cells distinct from FOXP3+ Tregs that coexpressed programmed cell death 1 (PD-1) and ICOS. These tumor-infiltrating lymphocyte CD4+ Th cells (CD4+ Th TILs) had a tissue-resident memory phenotype, were present in MHC class II-rich areas, and proliferated in the tumor, suggesting local antigen recognition. The T cell receptor repertoire of the PD-1+ICOS+ CD4+ Th TILs was oligoclonal, with T cell clones expanded in the tumor, but present at low frequencies in the periphery. Finally, these PD-1+ICOS+ CD4+ Th TILs were shown to recognize both tumor-associated antigens and tumor-specific neoantigens. Our findings provide an approach for isolating tumor-reactive CD4+ Th TILs directly ex vivo that will help define their role in the antitumor immune response and potentially improve future adoptive T cell therapy approaches.
科研通智能强力驱动
Strongly Powered by AbleSci AI