Interfacial β0 phase strengthening on the creep properties of TNM alloy has been investigated. The initial fully lamellar microstructure with fine-dispersed interfacial β0 phase was fabricated by powder hot isostatic pressing (P-HIP) and then carried out ageing treatment. The results indicated that the aged condition presented better microstructural stability and excellent creep resistance than the P-HIPed condition. Moreover, the ω phase precipitated within the β0 phase by stress-inducing. The β0/β0(ω) phase was not only effectively restricted the dislocation motion, twins and stacking faults propagation, but also delayed the α2 lamellae decomposition to maintain the integrity of the fully lamellar structure.