聚乙二醇化
聚乙二醇
胶体金
PEG比率
生物污染
表面改性
化学
共价键
纳米颗粒
活性氧
组合化学
硫醇
高分子化学
化学工程
纳米技术
材料科学
有机化学
生物化学
膜
物理化学
经济
工程类
财务
作者
Jing Kang,Fei‐Zheng Wu,Yao Xue,Zhi‐Han Li,Yu‐Xi Wang,Kun Liu
标识
DOI:10.1002/marc.202200035
摘要
PEGylation is the most effective antifouling method for the surface modification of gold nanoparticles (AuNPs). However, thiol-terminated polyethylene glycol (PEG) ligands tethered on the AuNPs are instable in serum and can detach from the AuNP surface, resulting in a significant reduce of their antifouling properties. Herein, it is reported that reactive oxygen species (ROS) is a major factor causing the detachment of PEG ligands from AuNP surfaces. By covalently backfilling dopamine-functionalized PEG on the AuNPs, the stability of PEG ligands on AuNP surface and the antifouling ability of AuNPs can be effectively improved. Tuning the balance between ROS and dopamine-functionalized PEG can be used as a new strategy to control the self-assembly of AuNPs and serum proteins.
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