检出限
抗坏血酸
甲氧苄啶
化学
色谱法
盐酸盐
电化学
尿
尿酸
碳糊电极
核化学
循环伏安法
电极
有机化学
生物化学
食品科学
物理化学
抗生素
作者
Ola G. Hussein,eman elzanfaly,Mohamed Abdelkawy,Hala E. Zaazaa,Shimaa A. Atty
出处
期刊:Journal of The Electrochemical Society
[The Electrochemical Society]
日期:2022-04-01
卷期号:169 (4): 043507-043507
被引量:2
标识
DOI:10.1149/1945-7111/ac638f
摘要
Phenazopyridine hydrochloride (PHZ) and Trimethoprim (TMP) are formulated together to treat urinary tract infections. The present work represents the first electrochemical sensor to simultaneously determine Phenazopyridine hydrochloride (PHZ) and Trimethoprim (TMP) with good anodic peak potential separation. A rapid, simple and sensitive electrochemical oxidation based on using multiwalled carbon nanotubes (CNT) and sugar polymer (PS) as modifier carbon paste (CNT/PS/MCPE) is described. The method was developed and validated in accordance with the guidelines of the International Council for Harmonisation (ICH). With a detection limit of 2 × 10 −7 M to 1 × 10 −4 M for both drugs with good recovery in pH 7. The method was then efficiently applied to determine PHZ and TMP in pharmaceutical formulation, human serum and urine. The proposed voltammetric method was statistically compared with the reported spectrophotometric method and the results obtained indicate no significant differences. Moreover, the fabricated sensor was applicable for the determination of PHZ and TMP in presence of common interfering molecules, ascorbic acid (AA) and uric acid (UA) which can be present in the plasma and urine. The method proved to be an excellent green analysis according to analytical eco-scale for greenness assessment.
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