倾向得分匹配
医学
危险系数
胰腺导管腺癌
肿瘤科
监测、流行病学和最终结果
内科学
比例危险模型
流行病学
队列
胰腺癌
人口
随机对照试验
癌症
外科
癌症登记处
置信区间
环境卫生
作者
Thomas Pausch,Xinchun Liu,Jiaqu Cui,Jishu Wei,Yi Miao,Ulrike Heger,Pascal Probst,Stephen Heap,Thilo Hackert
出处
期刊:Cancers
[MDPI AG]
日期:2021-12-23
卷期号:14 (1): 57-57
被引量:12
标识
DOI:10.3390/cancers14010057
摘要
Guidelines do not recommend resection surgery for oligometastatic pancreatic ductal adenocarcinoma (PDAC). However, reports in small samples of selected patients suggest that surgery extends survival. Thus, this study aims to gather evidence for the benefits of cancer-directed surgery (CDS) by analyzing a national cohort and identifying prognostic factors that aid the selection of candidates for CDS or recruitment into experimental trials. Data for patients with PDAC and hepatic metastasis were extracted from the population-based Surveillance, Epidemiology, and End Results database (SEER). The bias between CDS and non-CDS groups was minimized with Propensity Score Matching (PSM), and the prognostic role of CDS was investigated by comparing Kaplan-Meier estimators and Cox proportional hazard models. A total of 12,018 patients were extracted from the database, including 259 patients who underwent CDS that were 1:1 propensity score-matched with patients who did not receive CDS. CDS appeared to significantly prolong median overall survival from 5 to 10 months. Multivariate analysis revealed chemotherapy as a protective prognostic, whilst survival was impaired by old age and tumors that were poorly differentiated (Grades III-IV). These factors can be used to select patients likely to benefit from CDS treatment, which may facilitate recruitment into randomized controlled trials.
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