Research progress on cosmetic microneedle systems: Preparation, property and application

Recently, the combination of cosmetology and microneedle therapy has made great progress. Compared with direct injection, microneedles not only have functions of targeted delivery and high bioavailability, but also have characteristics of painless, mild and convenient. Also, it is beneficial to users' self-administration. Therefore, microneedles are more inclined to be treated by patients with cosmetic needs. Since microneedles were first applied in the cosmetic field in 2005, new products have emerged one after another, and the application of microneedles in wrinkle-removing, scar-treating, whitening, fat-reducing and other aspects has been greatly improved. Meanwhile, the composition of microneedles is a key factor affecting the preparation process, drug loading/release capacity, stability and final effect of microneedles. This paper reviews the commonly used matrix materials, loading drugs and preparation methods of cosmetic microneedles from the perspective of materials, in order to provide basic reference for the preparation of cosmetic microneedles. It is vital to detail the representative applications of microneedles in cosmetology. In conclusion, as a new tool, microneedle system shows great promise in cosmetic application.